Endocrine Abstracts

The pandemic increase of obesity, malnutrition and associated comorbidities encouraged intensive studies on energy balance control. Ghrelin is a brain-gut orexigenic hormone that is involved in both the short-term and long-term regulation of energy homeostasis. The aim of this research was to investigate the role of centrally applied ghrelin on the pituitary morphofunctional features and corticosterone secretion in normal-fed, food-restricted and obese 8 weeks old Wistar male ...

BMI over 30 kg/m2 is associated with lowest risk for osteoporosis and hip fracture in both sex. Increased body fat mass is followed with greater hip fracture risk, independently of BMI.Aim: Evaluate risk for osteoporosis in postmenopausal female with BMI 25–29.9 kg/m2 and influence of body fat mass on mineral bone density in overweight women.Material and methods: One hundred postmenopausal female, age 48&...

Introduction: Various non pancreatic tumors can cause hypoglycemia. Usually they are mesenchymal, retroperitoneal tumors or fibrosarcomas. Hemangiopericytoma is a rare type of mesenchymal tumor, which mostly develops in soft tissue and originates from the Zimmermann’s pericyte (modified smooth muscle cells).Case report: Fifty-nine-years old female patient with hypoglicemia was addmited to our department. Physical finding showed mild obesity and hype...

It is well known that weight losses in the range of 2.5–5% are able to improve factors of the metabolic syndrome such as insulin sensitivity. Several studies have been published concerning weight loss and subsequent changes in inflammatory markers and indicate that higher weight losses are necessary to affect the inflammatory markers than are needed to affect insulin sensitivity. Some data showed impairment of insulin sensitivity in diabetic patients during starvation. Th...

Aim: The aim of our study was to investigate is surgical stress induce alterations in insulin sensitivity in the course of cholecystectomy performed in two differnt procedures: as a open surgery and as laparascopic operation.Material and methods: The homeostasis assessment model (HOMA) was used to determine insulin sensitivity before and in the first, third and seventh day after the operation. Patients were divided int two groups: group A (open cholecyst...

Aim: To calculate mean HbA1c values in patients with type 2 diabetes mellitus in different therapy regiments.Material and methods: Ninety-nine diabetic persons was divided in three groups: group I (n=33) on oral hypoglucemic agents, group II (n=33) on one or two doses of insulin and group III (n=33) on intensive insulin therapy. We have calculated the mean values of HbA1c on the begining and 6 months after start of therapy regiment.<...

C-reactive protein (CRP) is closely associated with obesity and cardiovascular disease in both diabetic and nondiabetic subjects. The aim of our study was to investigate the effects of commonly prescribed antidiabetic agent metformin on CRP and insulin sensitivity in type 2 diabetes patients after 12 weeks of therapy. Twenty-three newly diagnosed type 2 diabetic patients (mean age: 49.74±2.03 years; mean BMI: 31.40±1.27 kg/m2) have been given metformin 2 g...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and acute insulin response (AIR) in patients with PHPT.Methods: In patients with PHPT (n=37; age: 57.72±8.29 years, BMI 26.22±4.37 kg/m2) euglycemic–hyp...

The inflammatory response in rat models of obesity and malnutrition was examined. Rats received standard chow (control), chow enriched with 30% lard (obese) or 70, 50, 40 and 40% of expected food intake weekly for 4 weeks (starved). The serum levels of cytokines were determined by ELISA, while the expression of cytokine mRNA in heart and liver was analyzed by real-time RT-PCR. The blood concentrations of pro-inflammatory cytokines (TNF, IL-1) and Th1 cytokine IFN-gamma were si...

The aim of the study was to investigate the influence of intracerebroventricular (ICV) injections of ghrelin on secretion of pro-inflammatory (TNF, IL-1, IFN-γ) and anti-inflammatory cytokines (TGF-β) in starved rats. Male Wistar rats (4 weeks old, 12 per group) were fed ad libitum or starved by caloric restriction (40% of chow consumed by their ad libitum fed controls from previous day) for 4 weeks. Afterwards, half of the animals in each group receive...